Tripartite motif-containing 55 identified as functional candidate for spontaneous cardiac hypertrophy in the rat locus cardiac mass 22

PR Prestes; FZ Marques; G Lopez-Campos; SA Booth; M McGlynn; P Lewandowski; LMD Delbridge; SB Harrap; FJ Charchar

Journal article

Tripartite motif-containing 55 identified as functional candidate for spontaneous cardiac hypertrophy in the rat locus cardiac mass 22

PR Prestes, FZ Marques, G Lopez-Campos, SA Booth, M McGlynn, P Lewandowski, LMD Delbridge, SB Harrap, FJ Charchar

Journal of Hypertension | Published : 2016

DOI: 10.1097/HJH.0000000000000875

Abstract

Background: Left ventricular (LV) hypertrophy is a risk factor for cardiovascular death, but the genetic factors determining LV size and predisposition to hypertrophy are not well understood. We have previously linked the quantitative trait locus cardiac mass 22 (Cm22) on chromosome 2 with cardiac hypertrophy independent of blood pressure in the spontaneously hypertensive rat. From an original cross of spontaneously hypertensive rat with F344 rats, we derived a normotensive polygenic model of spontaneous cardiac hypertrophy, the hypertrophic heart rat (HHR) and its control strain, the normal heart rat (NHR). Methods and results: To identify the genes and molecular mechanisms underlying spont..

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University of Melbourne Researchers

Lea Delbridge Author

Stephen Harrap Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by grants from the National Health and Medical Research Council of Australia (NHMRC) (project grant APP1034371 and 628643), the National Heart Foundation (grant G10M5155), and the Federation University Australia 'Self-sustaining Regions Research and Innovation Initiative', an Australian Government Collaborative Research Network (CRN). P.R.P. is supported by a Robert HT Smith Fellowship from Federation University. F.Z.M. is supported by NHMRC (APP1052659) and National Heart Foundation (PF12M6785) co-shared Early Career Fellowships.